Gene name:
Klk8 (Nrpn;Prss19) ;
Protein name:
Kallikrein-8 (mK8) ;
Alternative:
Serine protease 19 ;Neuropsin (NP) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with SPINK9.
Function:
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Subcellular Location:
Secreted
Cytoplasm
Shows a cytoplasmic distribution in the keratinocytes.
Protein Attributes:
50:
MGRPPPCAIQ | PWILLLLFMG | AWAGLTRAQG | SKILEGRECI | PHSQPWQAAL |
100:
FQGERLICGG | VLVGDRWVLT | AAHCKKQKYS | VRLGDHSLQS | RDQPEQEIQV |
150:
AQSIQHPCYN | NSNPEDHSHD | IMLIRLQNSA | NLGDKVKPVQ | LANLCPKVGQ |
200:
KCIISGWGTV | TSPQENFPNT | LNCAEVKIYS | QNKCERAYPG | KITEGMVCAG |
250:
SSNGADTCQG | DSGGPLVCDG | MLQGITSWGS | DPCGKPEKPG | VYTKICRYTT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Polyclonal Antibody for Mouse mK8
Polyclonal Antibody for Mouse mK8
Polyclonal Antibody for Mouse mK8
Monoclonal Antibody for Mouse mK8
Monoclonal Antibody for Mouse mK8
Monoclonal Antibody for Mouse mK8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus."
Chen Z.-L.
,
Yoshida S.
,
Kato K.
,
Momota Y.
,
Suzuki J.
,
Tanaka T.
,
Ito J.
,
Nishino H.
,
Aimoto S.
,
Kiyama H.
,
Shiosaka S.
J. Neurosci.15:5088-5097(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
BALB/c .
tissue :
Hippocampus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Czech II .
tissue :
Mammary gland .
4.
"Characterization of recombinant and brain neuropsin, a plasticity-related serine protease."
Shimizu C.
,
Yoshida S.
,
Shibata M.
,
Kato K.
,
Momota Y.
,
Matsumoto K.
,
Shiosaka T.
,
Midorikawa R.
,
Kamachi T.
,
Kawabe A.
,
Shiosaka S.
J. Biol. Chem.273:11189-11196(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION;MASS SPECTROMETRY
strain :
BALB/c .
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 85-260;TISSUE SPECIFICITY
strain :
C57BL/6 .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
11.
"Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin."
Kitayoshi H.
,
Inoue N.
,
Kuwae K.
,
Chen Z.-L.
,
Sato H.
,
Ohta T.
,
Hosokawa K.
,
Itami S.
,
Yoshikawa K.
,
Yoshida S.
,
Shiosaka S.
Arch. Dermatol. Res.291:333-338(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
15.
"Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice."
Hirata A.
,
Yoshida S.
,
Inoue N.
,
Matsumoto-Miyai K.
,
Ninomiya A.
,
Taniguchi M.
,
Matsuyama T.
,
Kato K.
,
Iizasa H.
,
Kataoka Y.
,
Yoshida N.
,
Shiosaka S.
Mol. Cell. Neurosci.17:600-610(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;DISRUPTION PHENOTYPE
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
23.
"Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins."
Kishibe M.
,
Bando Y.
,
Terayama R.
,
Namikawa K.
,
Takahashi H.
,
Hashimoto Y.
,
Ishida-Yamamoto A.
,
Jiang Y.-P.
,
Mitrovic B.
,
Perez D.
,
Iizuka H.
,
Yoshida S.
J. Biol. Chem.282:5834-5841(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;INDUCTION;DISRUPTION PHENOTYPE
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-257
tissue :
Hippocampus .